Επισκόπηση του βιολογικού κιρκάδιου ρολογιού στους ανθρώπους.

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Sleep Duration and Health Consequences

Several research studies have shown that sleep restriction to about 4 hours per night on 1 - 2 nights has significant effects on normal individuals. Studies have shown an increased heart rate and blood pressure(14), increased inflammation as measured by C-reactive protein (a marker of inflammation which can be measured in the blood and which has been proposed as a risk factor for coronary artery disease -(15), impaired glucose tolerance (which can be a prelude to the development of diabetes-(16), and increased hunger/appetite (which could promote obesity -(17) In addition, information obtained from questionnaires in large sample groups has also shown statistical associations between chronically reduced sleep duration and increased risk of hypertension (particularly in women) (18), (19); diabetes(20); and weight gain(21), (22), (23). These results are particularly meaningful because they agree with the results of studies that examined these issues by experimentally reducing the participants' time in bed. There is also a suggestion that sleep restriction may adversely affect immune function. In one study, young adults who had been given a flu shot after four nights of reduced sleep had less than half of the antibody response 10 days later compared with individuals having normal sleep at the time of vaccination (24). Changes in these clinical markers after only a few nights of partial sleep loss typically reverse when normal sleep is allowed. However, it is important to recognize that many of the above studies examined the effects of relatively short-term alteration in sleep duration but many individuals in the community may have chronic partial sleep deprivation. The consequences and reversibility of any consequences in this regard are not known.

The results of studies done to date imply that numerous health consequences could be associated with sleep restriction. In contrast, increased sleep duration has not been associated with immediate negative health consequences.

Knutson KL, Phelan J, Paskow MJ, Roach A, Whiton K, Langer G, et al. The National Sleep Foundation’s sleep health index. Sleep health. 2017;3(4):234–40.

http://sleepforkids.org/pdf/ClassroomGuide.pdf 
 Dr. Rafael Pelayo, MD
Stanford Sleep Disorders Clinic, Stanford, CA

https://www.protagon.gr/epikairotita/sto-viologiko-roloi-to-nobel-iatrikis-2017-44341487447

Νομπέλ Ιατρικής 2017: Πώς έσπασαν τον κώδικα του βιολογικού ρολογιού Οι Τζέφρι Χολ, Μάικλ Ρόσμπας και ο Μάικλ Γιανγκ βραβεύθηκαν για τις ανακαλύψεις τους στους μοριακούς μηχανισμούς που ελέγχουν τον κιρκαδιανό ρυθμό. Τα βήματα για την ανακάλυψη και η αναζήτηση του γονιδίου που ρυθμίζει το βιολογικό ρολόι Πηγή: Protagon.gr

Νομπέλ Ιατρικής 2017: Πώς έσπασαν τον κώδικα του βιολογικού ρολογιού Οι Τζέφρι Χολ, Μάικλ Ρόσμπας και ο Μάικλ Γιανγκ βραβεύθηκαν για τις ανακαλύψεις τους στους μοριακούς μηχανισμούς που ελέγχουν τον κιρκαδιανό ρυθμό. Τα βήματα για την ανακάλυψη και η αναζήτηση του γονιδίου που ρυθμίζει το βιολογικό ρολόι Πηγή: Protagon.gr

Νομπέλ Ιατρικής 2017: Πώς έσπασαν τον κώδικα του βιολογικού ρολογιού Πηγή: Protagon.gr